Prolonged post-ictal encephalopathy (PPIE)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Prolonged post-ictal encephalopathy (PPIE). This is prolonged confusion after seizures. It lasts 4 to 10 days. Fully referenced neurology checklist.

Clinical features

  • This is prolonged confusion after seizures
  • It lasts 4 to 10 days
  • It may be recurrent

Risk factors

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Differential diagnosis

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Electroencephalogram (EEG)

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References

  1. Biton V, Gates JR, dePadua Sussman L. Prolonged postictal encephalopathy. Neurology 1990; 40:963-966.
  2. Langheinrich TC, Chattopadhyay A, Kuc S, Reuber M. Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? Epilepsy Behav 2005; 7:548-551.
  3. Fagan KJ, Lee SI. Prolonged confusion following convulsions due to generalized nonconvulsive status epilepticus. Neurology 1990; 40:1689-1694.
  4. Karper LP, Salloway SP, Seibyl JP, Krystal JH. Prolonged postictal encephalopathy in two patients with clozapine-induced seizures. J Neuropsychiatry Clin Neurosci 1992; 4:454-457.

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