Progressive supranuclear palsy (PSP): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Progressive supranuclear palsy (PSP): clinical features. Oculomotor dysfunction, Postural instability, Akinesia. Fully referenced neurology checklist.
Core clinical domains
- Oculomotor dysfunction
- Postural instability
- Akinesia
- Cognitive dysfunction
Facial features
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Ophthalmic features
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Postural and gait abnormalities
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Bulbar features
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Applause sign
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Postural signs
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Speech impairments
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Other features
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Premorbid features
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Poor prognostic markers
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References
- Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol 2009; 8:270-279.
- Litvan I, Agid A, Calne D, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-PSP International Workshop. Neurology 1996; 47:1-9.
- Brazis PW, Masdeu JC, Biller J. Localization in Clinical Neurology. Lippincott Williams & Wilkins Philadelphia 2007 p445.
- Rojo A, Pernaute RS, Fontan A, et al. Clinical genetics of familial progressive supranuclear palsy. Brain 1999; 122:1233-1245.
- Höglinger GU, Respondek G, Stamelou M, et al; Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord 2017; 32:853-864.
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