Primary progressive aphasia (PPA): logopenic variant (lvPPA)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Primary progressive aphasia (PPA): logopenic variant (lvPPA). Progranulin (GRN). Fully referenced neurology checklist.
Genetic mutations
- Progranulin (GRN)
- Microtubule-associated protein tau (MAPT)
Pathological sites
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Clinical features
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Relatively spared speech functions
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Diagnostic criteria: core features
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Diagnostic criteria: supportive features
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Differentiating features from other PPA variants
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Other differentials
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Synonym
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References
- Henry ML, Gorno-Tempini ML. The logopenic variant of primary progressive aphasia. Curr Opin Neurol 2010; 23:633-637.
- Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.
- Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011; 76:1006-1014.
- Seelar H, Rohrer JD, Pijnenburg AL, Fox NC, van Swieten JC. Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review. JNNP 2011; 82:476-486.
- Chare L, Hodges JR, Leyton CE, et al. New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications. JNNP 2014; 85:866–871.
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