Primary central nervous system lymphoma (PCNSL): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Primary central nervous system lymphoma (PCNSL): clinical features. This is a form of non-Hodgkin’s lymphoma (NHL). Fully referenced neurology checklist.

Epidemiology

  • This is a form of non-Hodgkin’s lymphoma (NHL)
  • The mean onset age is 50 years

Risk disorders

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Typical sites

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Types

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Clinical features

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Poor prognostic markers

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References

  1. Slone HW, Blake JJ, Shah R, Guttikonda S, Bourekas EC. CT and MRI findings of intracranial lymphoma. Am J Roentgenol 2005; 184:1679-1685.
  2. Gavrilovic IT, Abrey LE. Diagnosis and treatment of primary central nervous system lymphoma. Curr Oncol Rep 2005; 7:47-54.
  3. DeAngelis LM. Primary central nervous system lymphoma. JNNP 1999; 66:699-701.
  4. Ahle G, Touitou V, Cassoux N, et al. Optic nerve infiltration in primary central nervous system lymphoma. JAMA Neurol 2017; 74:1368-1373. 
  5. Grimm SA, McCannel CA, Omuro AM, et al. Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report. Neurology 2008; 71:1355-1360. 
  6. And 8 more. Subscribe to see the full list

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