Pregnancy and haemangioblastoma
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Pregnancy and haemangioblastoma. Associated pheochromocytoma may result in foetal loss. Fully referenced neurology checklist.
Manifestations in pregnancy
- Enlargement of cerebellar lesions may result in hydrocephalus
- Associated pheochromocytoma may result in foetal loss
- Spinal lesions present with back pain and paraesthesias in pregnancy
- Cervical spinal lesions may present with dysautonomia
Risk of enlargement in pregnancy
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Treatment
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Acronyms
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References
- Capone F, Profice P, Pilato F, Zollino M, Colosimo C, Di Lazzaro V. Spinal hemangioblastoma presenting with low back pain in pregnancy. Spine J 2013; 13:e27-e29.
- da Mota Silveira Rodrigues A, Simões Fernandes F, Farage L, et al. Pregnancy-induced growth of a spinal hemangioblastoma: presumed mechanisms and their implications for therapeutic approaches. Int J Womens Health 2018; 10:325-328.
- Laviv Y, Wang JL, Anderson MP, Kasper EM. Accelerated growth of hemangioblastoma in pregnancy: the role of proangiogenic factors and upregulation of hypoxia-inducible factor (HIF) in a non-oxygen-dependent pathway. Neurosurg Rev 2019; 42:209-226.
- Frantzen C, Kruizinga RC, van Asselt SJ, et al. Pregnancy-related hemangioblastoma progression and complications in von Hippel-Lindau disease. Neurology 2012; 79:793-796.
- Ma XJ, Zhang GB, Guo TX, et al. Management and outcomes of pregnant patients with central nervous system hemangioblastoma. J Clin Neurosci 2018; 57:126-130.
