POEMS syndrome: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

POEMS syndrome: clinical features. This is a subacute progressive sensorimotor neuropathy. Fully referenced neurology checklist.

Polyneuropathy

  • This is a subacute progressive sensorimotor neuropathy
  • It is a length-dependent mixed axonal and demyelinating neuropathy
  • The onset is often with positive symptoms before progressive weakness
  • Only half of cases start with neuropathy

Organ involvement

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Endocrine features

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M protein

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Skin lesions

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Other features

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Proposed major diagnostic criteria

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Proposed minor diagnostic criteria (≥2 required)

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Poor prognostic features

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Acronyms

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Synonym

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References

  1. So YT. Immune-mediated neuropathies. Continuum (Minneap Minn) 2012; 18:85-105.
  2. Mauerman ML, Sorenson EJ, Dispenzieri A, et al. Uniform demyelination and more severe axonal loss distinguish POEMS syndrome from CIDP. JNNP 2012; 83:480-486.
  3. Arimura K. Early recognition of POEMS syndrome: what is the role of neurophysiology? JNNP 2012; 83:474.
  4. Riccio A, Natale D, Pettinato G, Sparano L, Petto A, Puzziello A. Castleman's disease. Ann Rheum Dis 2001; 60:176.
  5. Naddaf E, Dispenzieri A, Mandrekar J, Mauermann ML. Clinical spectrum of Castleman disease-associated neuropathy. Neurology 2016; 87:2457-2462.
  6. And 11 more. Subscribe to see the full list

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