Paroxysmal exercise-induced dyskinesia (PEID)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Paroxysmal exercise-induced dyskinesia (PEID). This is usually caused by mutations in the SLC2A1 (GLUT1) gene. Fully referenced neurology checklist.
Genetics
- This is usually caused by mutations in the SLC2A1 (GLUT1) gene
- The gene encodes the glucose transporter
- Some cases car caused by mutations in the ECHS1 gene
- The mutations may also be sporadic
Features of dyskinesia
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Triggers for attacks
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Relieving factors
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Possible associated symptoms
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Possible associated diseases
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Differential diagnosis: other paroxysmal exercise induced dyskinesias
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Investigations
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Treatment
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References
- Bhattacharyya KB, Basu S, Ray AD, Bhattacharya S. Sporadic paroxysmal exercise induced dystonia: report of a case and review of the literature. Neurol India 2000; 48:401-402.
- Unterberger I, Trinka E. Diagnosis and treatment of paroxysmal dyskinesia revisited. Ther Adv Neurol Disord 2008; 1:67-74.
- Dale RC, Melchers A, Fung VSC, Grattan-Smith P, Houlden H, Earl J. Familial paroxysmal exercise-induced dystonia: atypical presentation of autosomal dominant GTP-cyclohydrolase 1 deficiency. Dev Med Child Neurol 2010; 52:583-586.
- Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol 2011; 18:5-18.
- Olgiati S, Skorvanek M, Quadri M, et al. Paroxysmal exercise-induced dystonia within the phenotypic spectrum of ECHS1 deficiency. Mov Disord 2016; 31:1041-1048.
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