Paroxysmal dysarthria ataxia (PDA)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Paroxysmal dysarthria ataxia (PDA). Secondary types are related to lesions around the red nucleus. Fully referenced neurology checklist.

Pathology

  • Secondary types are related to lesions around the red nucleus
  • It is caused by dysfunction of the cerebellothalamocortical pathway

Classification

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Variants

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Secondary causes

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Onset features

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Clinical pattern

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Clinical features

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Magnetic resonance imaging (MRI) brain

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Other investigations

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Treatment of secondary types

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References

  1. Marcel C, Anheim M, Flamand-Rouvière C, et al. Symptomatic paroxysmal dysarthria-ataxia in demyelinating diseases. J Neurol 2010; 257:1369-1372.
  2. Li Y, Zeng C, Luo T. Paroxysmal dysarthria and ataxia in multiple sclerosis and corresponding magnetic resonance imaging findings. J Neurol 2011; 258:273-276.
  3. Matsui M, Tomimoto H, Sano K, Hashikawa K, Fukuyama H, Shibasaki H. Paroxysmal dysarthria and ataxia after midbrain infarction. Neurology 2004; 63:345-347. 
  4. Maramattom BV. Paroxysmal dysarthria ataxia-tremor-blepharospasm syndrome in Bickerstaff brainstem encephalitis; a variant of paroxysmal dysarthria ataxia syndrome. Neurol India 2022; 70:437-438.
  5. Ferrante E, Marazzi MR, Trimboli M, Dalla Costa D, Erminio C, Nobili L. Brainstem lesion causing paroxysmal ataxia, dysarthria, diplopia and hemifacial spasm (PADDHS). Epileptic Disord 2019; 21:389-390.
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