Parkinson's disease (PD): timeline and progression
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Parkinson's disease (PD): timeline and progression. Hyposmia, Constipation, Bladder symptoms. Fully referenced neurology checklist.
Prodrome: 20 years before motor phase
- Hyposmia
- Constipation
- Bladder symptoms
Prodrome: 10 years before motor phase
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Clinical onset
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Progression: 5 years after onset
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Progression: 10 years after onset
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Progression: 15 years after onset
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Progression: 20 years after onset
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Progression course
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References
- Hawkes CH, Tredici KD, Braak H. A timeline for Parkinson's disease. Parkinsonism Relat Disord 2010; 16:79-84.
- Maetzler W, Liepelt I, Berg D. Progression of Parkinson’s disease in the clinical phase: potential markers. Lancet Neurol 2009; 8:1158-1171.
- Poewe W. The natural history of Parkinson's disease. J Neurol 2006; 253 (Suppl 7):VII/2-VII/6.
- Verschuur CVM, Suwijn SR, Boel JA, et al; LEAP Study Group. Randomized delayed-start trial of levodopa in Parkinson's disease. N Engl J Med 2019; 380:315-324.
