Painful legs moving toes (PLMT)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Painful legs moving toes (PLMT). Idiopathic, Peripheral neuropathy (PN), Radiculopathies e.g. Herpes zoster. Fully referenced neurology checklist.

Causes

  • Idiopathic
  • Peripheral neuropathy (PN)
  • Radiculopathies e.g. Herpes zoster
  • Myelitis
  • Cauda equina lesions 
  • Nerve root lesions
  • Neuroleptics
  • Chemotherapy
  • Wilson's disease
  • Systemic diseases e.g. HIV
  • Dementia with Lewy bodies (DLB)

Types

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Clinical features

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Variants

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Drug treatments

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Non-drug treatments

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References

  1. Liu R, Moizuddin M, Hung S. Painful legs and moving toes-case report and review of the literature. BJMP 2011; 4:a431.
  2. Renard D, Taieb G, Castelnovo G, Labauge P. Teaching Video Neuroimages: Painful legs, moving toes associated with partial transverse myelitis. Neurology 2010; 75:e74.
  3. Madokoro Y, Mizuno M, Kawashima S, Okita K, Matsukawa N. Painful legs and moving toes syndrome associated with dementia with Lewy bodies responsive to rotigotine-induced analgesia. Neurol Sci 2022; 43:6569-6570. 
  4. Schoenen J, Gonce M, Delwaide PJ. Painful legs and moving toes: a syndrome with different physiopathologic mechanisms. Neurology (Cleveland) 1984; 34:1108-1112.
  5. Miyakawa T, Yoshimoto M, Takebayashi T, Yamashita T. Case Reports: Painful limbs/moving extremities: report of two cases. Clin Orthop Relat Res 2010; 468:3419-3425.
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