Oxcarbazepine: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Oxcarbazepine: clinical use. Oxcarbazepine is a sodium channel inhibitor. It is the keto analogue of Carbamazepine. Fully referenced neurology checklist.
Mechanism of action
- Oxcarbazepine is a sodium channel inhibitor
- It is the keto analogue of Carbamazepine
- It has less side effects than Carbamazepine
Dosing
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Indications
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Precautions
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Dermatological side effect: skin eruption
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Dermatological side effect: DRESS syndrome: features
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Neurological side effects
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Hyponatraemia
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Genitourinary side effects
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Systemic side effects
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References
- Shorvon S. Oxcarbazepine: a review. Seizure 2000; 9:75-79.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Smith PE; UK Oxcarbazepine Advisory Board. Clinical recommendations for oxcarbazepine. Seizure 2001; 10:87-91.
- Barcs G, Walker EB, Elger CE, et al. Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia 2000; 41:1597-1607.
- Gelisse P, Genton P, Kuate C, Pesenti A, Baldy-Moulinier M, Crespel A. Worsening of seizures by oxcarbazepine in juvenile idiopathic generalized epilepsies. Epilepsia 2004; 45:1282-1286.
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