Oxcarbazepine: adverse effects

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Oxcarbazepine: adverse effects. A maculopapular skin eruption develops in 10% of users. Fully referenced neurology checklist.

Dermatological side effect: skin eruption

  • A maculopapular skin eruption develops in 10% of users
  • There is cross reactivity with Carbamazepine in 25-30% of cases
  • The risk is highest in Asians
  • The risk alleles are HLA-B*40:02, DRB1*04:03, B*15:02, and A*3201

Dermatological side effect: DRESS syndrome: features

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Neurological side effects

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Hyponatraemia

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Genitourinary side effects

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Systemic side effects

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References

  1. Shorvon S. Oxcarbazepine: a review. Seizure 2000; 9:75-79. 
  2. Moon J, Kim TJ, Lim JA, et al. HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption. Epilepsia 2016; 57:1879-1886.
  3. Chen CB, Hsiao YH, Wu T, et al; Taiwan Severe Cutaneous Adverse Reaction Consortium. Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians. Neurology 2017; 88:78-86.
  4. Xu J, Shi X, Qiu Y, Zhang Y, Chen S, Shi Y, Deng Y. Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse reactions in Eastern Han Chinese population. Seizure 2019; 65:25-30. 
  5. Bosdure E, Cano A, Roquelaure B, et al. Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure. Arch Pediatr 2004; 11:1073-1077. 
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