Other familial pituitary adenoma syndromes
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Other familial pituitary adenoma syndromes. This is caused by MEN1 activating gene mutations. Fully referenced neurology checklist.
Multiple endocrine neoplasia type 1 (MEN1)
- This is caused by MEN1 activating gene mutations
- The gene codes for menin
- It manifests with:
- Primary hyperparathyroidism
- Pancreatic neuroendocrine tumours
- Pituitary adenomas: especially prolactinomas
Multiple endocrine neoplasia type 4 (MEN4)
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McCune Albright syndrome
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Familial isolated pituitary adenomas (FIPA)
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Pituitary blastoma with Cushing’s syndrome
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Xq26.3 microdeletions: manifestations
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MEN syndromes without pituitary adenomas: MEN2
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MEN syndromes without pituitary adenomas: MEN3
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Carney complex
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References
- Schernthaner-Reiter MH, Trivellin G, Stratakis CA. MEN1, MEN4, and Carney complex: pathology and molecular genetics. Neuroendocrinology 2016;1 03:18-31.
- Vandeva S, Vasilev V, Vroonen L, et al. Familial pituitary adenomas. Ann Endocrinol (Paris) 2010; 71:479-485.
- Arafah BM, Nasrallah MP. Pituitary tumors: pathophysiology, clinical manifestations and management. Endocr Relat Cancer 2001; 8:287-305.
- Levy A. Pituitary disease: presentation, diagnosis, and management. JNNP 2004; 75(Suppl 3):iii47-iii52.
- Thakker RV. Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4). Mol Cell Endocrinol 2014; 386:2-15.
- And 3 more. Subscribe to see the full list
