Non-lesional late-onset epilepsy (NLLOE)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Non-lesional late-onset epilepsy (NLLOE). The onset age is ≥ 55 years. It has mild and severe types. Fully referenced neurology checklist.

Demographic features

  • The onset age is ≥ 55 years
  • It has mild and severe types
  • It may manifest as late onset epilepsy of unknown origin (LOEOU)

Clinical presentations

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Differential diagnosis: causes of late onset epilepsy

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Investigations to identify seizure focus

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Drug treatment

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Epilepsy surgery

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Other interventional treatments

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References

  1. Süße M, Hamann L, Flöel A, von Podewils F. Nonlesional late-onset epilepsy: semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. Epilepsy Behav 2018; pii: S1525-5050(18)30363-9 (Epub ahead of print).
  2. Aguglia U, Gambardella A, Le Piane E, et al. Mild non-lesional temporal lobe epilepsy. A common, unrecognized disorder with onset in adulthood. Can J Neurol Sci 1998; 25:282-286.
  3. Morano A, Cerulli Irelli E, Salamone EM, et al. Late-onset seizures and epilepsy: electroclinical features suggestive of autoimmune etiology. Front Neurol 2022; 13:924859.
  4. Lee SK, Yun CH, Oh JB, et al. Intracranial ictal onset zone in nonlesional lateral temporal lobe epilepsy on scalp ictal EEG. Neurology 2003; 61:757-764.
  5. Wetjen NM, Marsh WR, Meyer FB, et al. Intracranial electroencephalography seizure onset patterns and surgical outcomes in nonlesional extratemporal epilepsy. J Neurosurg 2009; 110:1147-1152.
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