MOGHE
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
MOGHE. This is a drug-resistant epilepsy. More than 70% have SLC35A2 gene mutations. Fully referenced neurology checklist.
Genetics and pathology
- This is a drug-resistant epilepsy
- More than 70% have SLC35A2 gene mutations
- There is oligodendroglial cell proliferation in the white matter and deep cortex
Epidemiological features
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Clinical phenotypes
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Clinical features
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Differential diagnosis
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Electroencephalogram (EEG)
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Magnetic resonance imaging (MRI) brain
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Pathological features
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Treatment
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Eponym
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Synonym
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References
- Zhan Y, Chen S, Jin Z, et al. Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy: a systematic review. Neurol Genet 2025; 11:e200240.
- Liu X, Zhu Y, Liu Q, et al. Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy. Epilepsia Open 2023; 8:898-911.
- Bonduelle T, Hartlieb T, Baldassari S, et al. Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE). Acta Neuropathol Commun 2021; 9:3.
- Mendes Coelho VC, Morita-Sherman M, et al. Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort. Epilepsia 2021; 62:1429-1441.
- Dimova PS, Metodiev D, Todorov T, et al. Clinical characteristics and multimodal imaging can help diagnosing and treating mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy. Epileptic Disord 2024; 26:662-675.
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Related checklists
- Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS)
- Temporal lobe epilepsy with amygdala enlargement (TLE-AE)
- Autosomal dominant epilepsy with auditory features (ADEAF)
- Familial mesial temporal lobe epilepsy (FMTLE)
- Familial partial epilepsy with variable foci (FPEVF)
- Generalised-onset seizures with focal evolution (GOFE)
- Transient epileptic amnesia (TEA)
- Non-lesional late-onset epilepsy (NLLOE)
- Geschwind syndrome
