Neuropsychiatric systemic lupus erythematosus (NPSLE): treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Neuropsychiatric systemic lupus erythematosus (NPSLE): treatment. Intravenous Methylprednisolone 1g daily for 3 days. Fully referenced neurology checklist.
First line treatment of vasculitic or inflammatory features
- Intravenous Methylprednisolone 1g daily for 3 days
- Cyclophosphamide 0.5-1g/square meter monthly for 6 months
- Convert to maintenance immunosuppressants if response is complete
Second line treatment options
Locked: subscribe to see this section.
Treatment of thrombotic features
Locked: subscribe to see this section.
Symptomatic treatments
Locked: subscribe to see this section.
Investigational treatments
Locked: subscribe to see this section.
References
- Popescu A, Kao AH. Neuropsychiatric systemic lupus erythematosus. Curr Neuropharmacol 2011; 9:449-457.
- Magro-Checa C, Zirkzee EJ, Huizinga TW, Steup-Beekman GM. Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives. Drugs 2016; 76:459-483.
- Hussain A, Mir TH, Dar MA, et al. Systemic lupus erythematous presenting as catatonia and its response to electroconvulsive therapy. Indian J Psychol Med 2015; 37:456-459.
