Myasthenia gravis (MG): differential diagnosis

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Myasthenia gravis (MG): differential diagnosis. LEMS does not progress caudally as in MG. Fully referenced neurology checklist.

Lambert Eaton myasthenic syndrome (LEMS)

  • This does not present with initial ocular or isolated upper limb weakness as in MG
  • LEMS does not progress caudally as in MG

Congenital myasthenic syndromes (CMS

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Mitochondrial diseases

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Myopathies

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Other neuromuscular differentials

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Other neurological differentials

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Systemic differentials

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Drug-induced MG

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MG overdiagnosis: causes

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References

  1. Sathasivam S. Diagnosis and management of myasthenia gravis. Prog Neurol Psychiatry 2014; 18:6-14.
  2. Thanvi BR, Lo TC. Update on myasthenia gravis. Postgrad Med J 2004; 80:690-700.
  3. Wirtz PW, Sotodeh M, Nijnuis M, et al. Difference of distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. JNNP 2002; 73:766-768.
  4. Garg N, Yiannikas C, Hardy TA, et al. Late presentations of congenital myasthenic syndromes: how many do we miss? Muscle Nerve 2016; 54:721-727. 
  5. Beeson D. Congenital myasthenic syndromes. ACNR 2005; 4:12-13.
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