Myasthenia gravis (MG) AChR antibodies
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Myasthenia gravis (MG) AChR antibodies. This is positive in 85% of generalised MG. Fully referenced neurology checklist.
Routine AChR antibody test
- This is positive in 85% of generalised MG
- Levels do not correlate with disease severity
AChR antibody radioimmunoprecipitation assay (RIPA)
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Clustered AChR antibody test
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Causes of false positive AChR antibody titers
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Causes of false negative AChR antibody test
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References
- Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2010; 17:893-902.
- Thanvi BR, Lo TCN. Update on myasthenia gravis. Postgrad Med J 2004; 80:690–700.
- Jayam Trouth A, Dabi A, Solieman N, Kurukumbi M, Kalyanam J. Myasthenia gravis: a review. Autoimmune Dis 2012; 2012:874680.
- Zara P, Chessa P, Deiana GA, et al. Risk of false acetylcholine receptor autoantibody positivity by radioimmunoprecipitation assay in clinical practice. Neurology 2025; 104:e213498.
- Zhao G, Wang X, Yu X, Zhang X, Guan Y, Jiang J. Clinical application of clustered-AChR for the detection of SNMG. Sci Rep 2015; 5:10193.
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