Multiple sclerosis (MS): symptomatic treatments
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Multiple sclerosis (MS): symptomatic treatments. Amantadine, Modafinil, Methylphenidate. Fully referenced neurology checklist.
Fatigue: drug treatments
- Amantadine
- Modafinil
- Methylphenidate
- A recent systematic review however suggested that these are all no better than placebo
Fatigue: non-drug treatments
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Urinary symptoms
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Spasticity
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Tremors
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Tonic spasms
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Emotional lability
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Oscillopsia
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References
- Rejdak K, Jackson S, Giovannoni G. Multiple sclerosis: a practical overview for clinicians. Br Med Bull 2010; 95:79-104.
- Multiple sclerosis: management of multiple sclerosis in primary and secondary care. NICE clinical guidelines [CG186]. October 2014.
- Perry M, Swain S, Kemmis-Betty S, Guideline Development Group of the National Institute for Health and Care Excellence. Multiple sclerosis: summary of NICE guidelines. BMJ 2014; 349:g5701.
- Nourbakhsh B, Revirajan N, Morris B, et al. Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial. Lancet Neurol 2021; 20:38-48.
- Coe S, Cossington J, Collett J, et al. A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. JNNP 2019; 90:507-513.
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