Mpox: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Mpox: clinical features. Monkeypox infection is a Poxviridae zoonotic disease. It belongs to the genus Orthopoxvirus. Fully referenced neurology checklist.

Pathology

  • Monkeypox infection is a Poxviridae zoonotic disease
  • It belongs to the genus Orthopoxvirus
  • The natural reservoirs are possibly small mammals and primates
  • It is transmitted by close physical and sexual contact
  • It is also spread by respiratory droplets, blood, and semen
  • The incubation period is 7-21 days
  • It is a mild infection and most cases recover in weeks

Epidemiology

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Prodromal features

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Dermatological features

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Systemic features

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Neurological features

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Psychiatric features

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Differential diagnosis

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References

  1. Badenoch JB, Conti I, Rengasamy ER, et al. Neurological and psychiatric presentations associated with human monkeypox virus infection: a systematic review and meta-analysis. EClinicalMedicine 2022; 52:101644.
  2. Samaranayake L, Anil S. The monkeypox outbreak and implications for dental practice. Int Dent J 2022; 72:589-596. 
  3. Hasan S, Saeed S. Monkeypox disease: an emerging public health concern in the shadow of COVID-19 pandemic: an update. Trop Med Infect Dis 2022; 7:283.
  4. Sepehrinezhad A, Ashayeri Ahmadabad R, Sahab-Negah S. Monkeypox virus from neurological complications to neuroinvasive properties: current status and future perspectives. J Neurol 2022 (Online ahead of print).
  5. Pastula DM, Tyler KL. An overview of monkeypox virus and its neuroinvasive potential. Ann Neurol 2022; 92:527-531. 
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