Morvan's syndrome

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Morvan's syndrome. This is usually associated with CASPR2 antibody. It may be antibody-negative. Fully referenced neurology checklist.

Aetiology

  • This is usually associated with CASPR2 antibody
  • It may be antibody-negative

Neurological features

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Systemic features

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Differential diagnosis

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Treatment

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References

  1. Liguori R, Vincent A, Clover L, et al. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain 2001; 124:2417-2426.
  2. Vincent A, Bien CG, Irani S, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011; 10:759-772.
  3. Toosy AT, Burbridge SE, Pitkanen M, et al. Functional imaging correlates of fronto-temporal dysfunction in Morvan's syndrome. JNNP 2008; 79:734.
  4. Maskery M, Chhetri SK, Dayanandan R, Gall C, Emsley HC. Morvan syndrome: a case report with patient narrative and video. Neurohospitalist 2016; 6:32-35.
  5. Nawfal O, Agha M, Makki A, Beydoun A. Refractory Morvan syndrome responsive to rituximab: a case report and review of the literature. Neuromuscul Disord 2022; 32:682-686.

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