Monoclonal gammopathy associated myopathies (MGAM)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Monoclonal gammopathy associated myopathies (MGAM). Sporadic late-onset nemaline myopathy (SLONM). Fully referenced neurology checklist.
Types
- Sporadic late-onset nemaline myopathy (SLONM)
- Light chain (AL) amyloidosis myopathy
- Scleromyxedema with associated myopathy
- Monoclonal gammopathy-associated glycogen storage myopathy (MGGSM)
Onset features
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Clinical features
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Creatinine kinase (CK)
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Muscle biopsy: required stains
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Other investigations
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Treatment
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References
- Soontrapa P, Jones FJS, Milone M, et al. Clinicopathologic features, pathogenesis, and treatment of monoclonal gammopathy-associated myopathies. Neurology 2025; 105:e214101.
- Moshe-Lilie O, Banks G, Medvedova E, Masri A, Chahin N. Coexisting sporadic late onset nemaline myopathy and AL amyloid myopathy - incidental or related? Neuromuscul Disord 2022; 32:533-538.
- Wang M, Lei L, Chen H, et al. Monoclonal gammopathy with both nemaline myopathy and amyloid myopathy. Neuromuscul Disord 2017; 27:942-946.
