Hypernatraemic myopathy

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hypernatraemic myopathy. Craniopharyngioma, Germinoma, Mixed germ cell tumour, Pituitary adenoma. Fully referenced neurology checklist.

Causes

  • Craniopharyngioma
  • Germinoma
  • Mixed germ cell tumour
  • Pituitary adenoma
  • Langerhans cell histiocytosis
  • Glioma
  • Craniopharyngioma surgery

Neurological features

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Systemic features

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Differential diagnosis

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Muscle biopsy features

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Pituitary hormone tests

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Imaging

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Other investigations

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Treatment

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References

  1. Li Q, Bao L, Liu M, Zhang R, Shi H, Chen H. Hypothalamic hypernatremic myopathy: a single-center case series. Muscle Nerve 2023; 67:231-236.
  2. Huang MN, Chen JJ, Lee KL, Tseng FY, Yu CL, Hsieh SC. Hypernatremic myopathy caused by a hypothalamic mixed germ cell tumor mimicking polymyositis. Clin Rheumatol 2007; 26:1591-1594.
  3. Hiromatsu K, Kobayashi T, Fujii N, Itoyama Y, Goto I, Murakami J. Hypernatremic myopathy. J Neurol Sci 1994; 122:144-147. 
  4. Sabzghabaei F, Rastegar A. Adipsic hypernatremic myopathy. Iran J Kidney Dis 2015; 9:256-258.
  5. Zantut-Wittmann DE, Garmes HM, Panzan AD, Lima Mde O, Baptista MT. Severe rhabdomyolysis due to adipsic hypernatremia after craniopharyngioma surgery. Arq Bras Endocrinol Metabol 2007; 51:1175-1179.

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