Migraine prophylaxis: magnesium
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Migraine prophylaxis: magnesium. Migraine sufferers often have low magnesium. Fully referenced neurology checklist.
Relationship of magnesium to migraine
- Migraine sufferers often have low magnesium
- Low magnesium promotes cortical spreading depression
- Low magnesium also impairs serotonin receptor function
Benefit in magnesium in migraine prophylaxis
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Benefit of magnesium for acute migraine treatment
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Dose of magnesium in migraine prophylaxis
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Dose of magnesium in acute migraine treatment
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Side effects
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References
- Mauskop A, Varughese J. Why all migraine patients should be treated with magnesium. J Neural Transm (Vienna) 2012; 119:575-579.
- Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients 2015; 7:8199-8226.
- von Luckner A, Riederer F. Magnesium in migraine prophylaxis-is there an evidence-based rationale? a systematic review. Headache 2018; 58:199-209.
- Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain Physician 2016; 19:E97-E112.
- Karimi N, Razian A, Heidari M. The efficacy of magnesium oxide and sodium valproate in prevention of migraine headache: a randomized, controlled, double-blind, crossover study. Acta Neurol Belg 2019; doi: 10.1007/s13760-019-01101-x (Epub ahead of print).
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