Metronidazole encephalopathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Metronidazole encephalopathy. Liver dysfunction, Diabetes, Cancer. Fully referenced neurology checklist.
Predisposing factors
- Liver dysfunction
- Diabetes
- Cancer
Clinical features: acute irreversible cerebellar syndrome
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Clinical features: encephalopathy
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Other features of metronidazole toxicity
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Differential diagnosis
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Outcome
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Magnetic resonance imaging (MRI): features
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Magnetic resonance imaging (MRI): lesion locations
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References
- Bhattacharyya S, Darby RR, Raibagkar P, Gonzalez Castro LN, Berkowitz AL. Antibiotic-associated encephalopathy. Neurology 2016; 86:963-971.
- Ward F, Crowley P, Cotter PE. Acute cerebellar syndrome associated with metronidazole. Pract Neurol 2015; 15:298-299.
- Ng PS, Saini M. Reversible metronidazole-induced subacute cerebellar syndrome. QJM 2014; 107:1051-1052.
- Kuriyama A, Jackson JL, Doi A, Kamiya T. Metronidazole-induced central nervous system toxicity: a systematic review. Clin Neuropharmacol 2011; 34:241-247.
- Hobbs K, Stern-Nezer S, Buckwaiter MS, Fischbein N, Finlay Caulfield A. Metronidazole-induced encephalopathy: not always a reversible situation. Neurocrit Care 2015; 22:429-436.
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