Mast cell activation syndrome (MCAS): pathology

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Mast cell activation syndrome (MCAS): pathology. This comprises all disorders caused by mast cell activation. Fully referenced neurology checklist.

Pathology

  • This comprises all disorders caused by mast cell activation
  • It manifests as systemic anaphylaxis involving at least two organ systems
  • The pathology results from mast cell mediators and their metabolites
  • It presents with episodic symptoms

MCAS mediators and metabolites

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Classification

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Primary MCAS: types

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References

  1. Weiler CR, Austen KF, Akin C, et al. AAAAI Mast Cell Disorders Committee Work Group Report: mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol 2019; 144:883-896. 
  2. Frieri M. Mast cell activation syndrome. Clin Rev Allergy Immunol 2018; 54:353-365.

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