Mast cell activation syndrome (MCAS): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Mast cell activation syndrome (MCAS): clinical features. Hot water, Alcohol, Drugs, Stress, Exercise. Fully referenced neurology checklist.

Triggers for secondary MCAS

  • Hot water
  • Alcohol
  • Drugs
  • Stress
  • Exercise
  • Hormonal fluctuations
  • Infection
  • Pressure
  • Friction

Dermatological features

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Gastrointestinal features

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Cardiovascular features

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Respiratory features

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Other features

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Associated neuropsychiatric features

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Associated systemic features

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References

  1. Weiler CR, Austen KF, Akin C, et al. AAAAI Mast Cell Disorders Committee Work Group Report: mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol 2019; 144:883-896. 
  2. Frieri M. Mast cell activation syndrome. Clin Rev Allergy Immunol 2018; 54:353-365. 
  3. Boddaert N, Salvador A, Chandesris MO, et al. Neuroimaging evidence of brain abnormalities in mastocytosis. Transl Psychiatry 2017; 7:e1197.

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