Marchiafava-Bignami disease (MBD): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Marchiafava-Bignami disease (MBD): management. Magnetic resonance imaging (MRI). Fully referenced neurology checklist.
Magnetic resonance imaging (MRI) brain
- Magnetic resonance imaging (MRI)
- This shows reduced T1 and increased T2 signals in the lesions
- There may be contrast enhancement on MRI
- There is no significant mass effect
- It may show the ears of the Lynx sign: as in HSP with thin corpus callosum (SPG11)
Computed tomography (CT) head
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Treatment
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References
- Singer E, Bhatt K, Prashad A, Rudman L, Gadelmoula I, Michel G. Diagnosis and management of Marchiafava-Bignami disease, a rare neurological complication of long-term alcohol abuse. Discoveries (Craiova) 2023; 11:e168.
- Hillbom M, Saloheimo P, Fujioka S, Wszolek ZK, Juvela S, Leone MA. Diagnosis and management of Marchiafava-Bignami disease: review of CT/MRI confirmed cases. JNNP 2014; 85:168-173.
- Hoshino Y, Ueno Y, Shimura H, et al. Marchiafava-Bignami disease mimics motor neuron disease: case report. BMC Neurol 2013; 13:208.
- Pacheco FT, Rego MM, do Rego JI, da Rocha AJ. "Ears of the lynx" sign in a marchiafava-bignami patient: structural basis and fiber-tracking DTI contribution to the understanding of this imaging abnormality. J Neuroimaging 2014; 24:205-207.
- Riverol M, Samaranch L, Pascual B, et al. Forceps minor region signal abnormality "ears of the lynx": an early MRI finding in spastic paraparesis with thin corpus callosum and mutations in the spatacsin gene (SPG11) on chromosome 15. J Neuroimaging 2009; 19:52-60.
