Marchiafava-Bignami disease (MBD): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Marchiafava-Bignami disease (MBD): clinical features. This is demyelination and necrosis of the corpus callosum. Fully referenced neurology checklist.
Pathology
- This is demyelination and necrosis of the corpus callosum
- It involves the entire corpus callosum: it is just the splenium in other conditions
Demographic features
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Risk factors
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Classification
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Cognitive features
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Bulbar features
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Cortical features
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Other features
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References
- Hillbom M, Saloheimo P, Fujioka S, Wszolek ZK, Juvela S, Leone MA. Diagnosis and management of Marchiafava-Bignami disease: review of CT/MRI confirmed cases. JNNP 2014; 85:168-173.
- Hoshino Y, Ueno Y, Shimura H, et al. Marchiafava-Bignami disease mimics motor neuron disease: case report. BMC Neurol 2013; 13:208.
- Salazar G, Fragoso M, Español G, Cuadra L. Primary degeneration of the corpus callosum (Marchiafava-Bignami disease): 2 unusual clinical presentations. Neurologia 2013; 28:587-589.
- Singer E, Bhatt K, Prashad A, Rudman L, Gadelmoula I, Michel G. Diagnosis and management of Marchiafava-Bignami disease, a rare neurological complication of long-term alcohol abuse. Discoveries (Craiova) 2023; 11:e168.
- Sehgal V, Kesav P, Modi M, Ahuja CK. Acute Marchiafava-Bignami disease presenting as reversible dementia in a chronic alcoholic. BMJ Case Rep 2013; 2013:bcr2012008286.
