MADSAM (Lewis Sumner syndrome)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
MADSAM (Lewis Sumner syndrome). This is probably an asymmetrical variant of CIDP. It has a male predominance. Fully referenced neurology checklist.
Demographic features
- This is probably an asymmetrical variant of CIDP
- It has a male predominance
- The mean onset age is 40-50 years
Clinical features
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Differential diagnosis: similarities with MMN
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Differential diagnosis: differences with MMN
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Magnetic resonance imaging (MRI): features
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Other investigations
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Treatment
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Acronym
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References
- Viala K, Renie L, Maisonobe T, et al. Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. Brain 2004; 127:2010-2017.
- Kuwahara M, Numoto I, Kusunoki S. Multifocal nodular hypertrophy of trigeminal nerve in multifocal acquired demyelinating sensory and motor neuropathy. Neurol Neuroimmunol Neuroinflamm 2019; 6:e553.
- Verschueren A, Azulay JP, Attarian S, Boucraut J, Pellissier JF, Pouget J. Lewis-Sumner syndrome and multifocal motor neuropathy. Muscle Nerve 2005; 31:88-94.
- Saperstein DS, Amato AA, Wolfe GI, et al. Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. Muscle Nerve 1999; 22:560-566.
- Shimizu F, Oishi M, Sawai S, et al. Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy. JNNP 2019; 90:444-450.
