Chronic immune sensory polyradiculopathy (CISP)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Chronic immune sensory polyradiculopathy (CISP). This is a restricted form of CIDP. Fully referenced neurology checklist.

Pathology

  • This is a restricted form of CIDP
  • It preferentially affects large myelinated posterior root fibers

Clinical features

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Neurophysiology

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Cerebrospinal fluid (CSF) analysis

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Sensory rootlet biopsy: features

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Magnetic resonance imaging (MRI): features

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Treatment

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References

  1. Sinnreich M, Klein CJ, Daube JR, Engelstad J, Spinner RJ, Dyck PJ. Chronic immune sensory polyradiculopathy: a possibly treatable sensory ataxia. Neurology 2004; 63:1662-1669.
  2. Trip SA, Saifee T, Honan W, et al. Chronic immune sensory polyradiculopathy with cranial and peripheral nerve involvement. J Neurol 2012; 259:1238-1240.
  3. Clerici AM, Nobile-Orazio E, Mauri M, Squellati FS, Bono GG. Utility of somatosensory evoked potentials in the assessment of response to IVIG in a long-lasting case of chronic immune sensory polyradiculopathy. BMC Neurol 2017; 17:127.

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