Locked in syndrome (LIS): pathology
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Locked in syndrome (LIS): pathology. This is usually caused by lesions in the ventral pons. Fully referenced neurology checklist.
Pathology
- This is usually caused by lesions in the ventral pons
- It may also result from extensive bilateral corticobulbar and corticospinal tract destruction
- It may be transient or chronic
Classification
Locked: subscribe to see this section.
Primary causes
Locked: subscribe to see this section.
Iatrogenic causes
Locked: subscribe to see this section.
References
- Smith E, Delargy M. Locked-in syndrome. BMJ 2005; 330:406-409.
- Schnetzer L, McCoy M, Bergmann J, Kunz A, Leis S, Trinka E. Locked-in syndrome revisited. Ther Adv Neurol Disord 2023; 16:17562864231160873.
- Halan T, Ortiz JF, Reddy D, Altamimi A, Ajibowo AO, Fabara SP. Locked-in syndrome: a systematic review of long-term management and prognosis. Cureus 2021; 13:e16727.
- Senthilkumaran S, Balamurugan N, Karthikeyan N, Thirumalaikolundusubramanian P. Snakebite mimicking brain death: bedside clues. Indian J Crit Care Med 2021; 25:1464.
