Locked in syndrome (LIS): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Locked in syndrome (LIS): clinical features. Quadriplegia, Anarthria, Lower cranial nerve paralysis. Fully referenced neurology checklist.
Defining features
- Quadriplegia
- Anarthria
- Lower cranial nerve paralysis
Other associated features
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Possible associated involuntary movements
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Possible associated impairments
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Usually preserved features
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Good prognostic features
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Differential diagnosis
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Outcome
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References
- Smith E, Delargy M. Locked-in syndrome. BMJ 2005; 330:406-409.
- Schnetzer L, McCoy M, Bergmann J, Kunz A, Leis S, Trinka E. Locked-in syndrome revisited. Ther Adv Neurol Disord 2023; 16:17562864231160873.
- Halan T, Ortiz JF, Reddy D, Altamimi A, Ajibowo AO, Fabara SP. Locked-in syndrome: a systematic review of long-term management and prognosis. Cureus 2021; 13:e16727.
- Senthilkumaran S, Balamurugan N, Karthikeyan N, Thirumalaikolundusubramanian P. Snakebite mimicking brain death: bedside clues. Indian J Crit Care Med 2021; 25:1464.
