Lithium toxicity: neurological features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lithium toxicity: neurological features. This is a syndrome of irreversible lithium-effectuated neurotoxicity. Fully referenced neurology checklist.
SILENT syndrome: definition
- This is a syndrome of irreversible lithium-effectuated neurotoxicity
- It is persistent cerebellar dysfunction after lithium poisoning
- It is possibly due to demyelination
SILENT syndrome: clinical features
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Other neurological features
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Differential diagnosis
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Investigations
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Treatment
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References
- 1Newman PK, Saunders M. Lithium neurotoxicity. Postgrad Med J 1979; 55:701-703.
- Adityanjee, Munshi KR, Thampy A. The syndrome of irreversible lithium-effectuated neurotoxicity. Clin Neuropharmacol 2005; 28:38-49.
- Farouji A, Battah A, Ahmad AS, Farouji I, Miller R. A unique case of the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) presenting with multiple neurological sequelae. Cureus 2023; 15:e38102.
- Jørgensen JS, Landschoff Lassen L, Wegener M. Lithium-induced downbeat nystagmus and horizontal gaze palsy. Open Ophthalmol J 2016; 10:126-128.
- Rust H, Lutz N, Honegger F, et al. Periodic alternating nystagmus in a patient on long-term lithium medication. J Neurol Sci 2016; 369:252-253.
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