Lennox Gastaut syndrome (LGS): treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lennox Gastaut syndrome (LGS): treatment. Valproate: this may be of choice, Felbamate, Lamotrigine, Topiramate. Fully referenced neurology checklist.
Early-stage drug treatments: especially for drop attacks
- Valproate: this may be of choice
- Felbamate
- Lamotrigine
- Topiramate
Later drug treatment considerations
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Drug treatments to use with caution
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Interventional treatments
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References
- van Rijckevorsel K. Treatment of Lennox-Gastaut syndrome: overview and recent findings. Neuropsychiatr Dis Treat 2008: 4:1001-1019.
- Stafstrom CE. Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide. Neuropsychiatr Dis Treat 2009; 5:547–551.
- Bourgeois BF, Douglass LM, Sankar R. Lennox-Gastaut syndrome: A consensus approach to differential diagnosis. Epilepsia 2014; 55(Suppl 4):4-9.
- Arzimanoglou A, French J, Blume WT, et al. Lennox-Gastaut syndrome: a consensus approach to diagnosis, assessment, management, and trial methodology. Lancet Neurol 2009; 8:82-93.
- Zhang Y, Wang Y, Zhou Y, Zhang L, Yu L, Zhou S. Therapeutic effects of the ketogenic diet in children with Lennox-Gastaut syndrome. Epilepsy Res 2016; 128:176-180.
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