Lennox Gastaut syndrome (LGS): investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Lennox Gastaut syndrome (LGS): investigations. 2.5 Hz diffuse slow spike and wave (SSW) complexes: in wakefulness. Fully referenced neurology checklist.

Electroencephalogram (EEG): features

  • 2.5 Hz diffuse slow spike and wave (SSW) complexes: in wakefulness
  • Generalized paroxysmal fast wave activity (GPFA): in slow sleep
  • 10–20 Hz fast rhythm: in sleep

Magnetic resonance imaging (MRI)

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Positron emission tomography (PET)

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References

  1. van Rijckevorsel K. Treatment of Lennox-Gastaut syndrome: overview and recent findings. Neuropsychiatr Dis Treat 2008: 4:1001-1019.
  2. Stafstrom CE. Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide. Neuropsychiatr Dis Treat 2009; 5:547–551.
  3. Bourgeois BF, Douglass LM, Sankar R. Lennox-Gastaut syndrome: A consensus approach to differential diagnosis. Epilepsia 2014; 55(Suppl 4):4-9.
  4. Arzimanoglou A, French J, Blume WT, et al. Lennox-Gastaut syndrome: a consensus approach to diagnosis, assessment, management, and trial methodology. Lancet Neurol 2009; 8:82-93. 
  5. Nizami FM, Trivedi S, Kalita J. A systematic review of electroencephalographic findings in Lennox-Gastaut syndrome. Epilepsy Res 2024; 205:107406.

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