Lamotrigine: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lamotrigine: clinical use. Lamotrigine modulates the voltage gated sodium channel (VGSC). Fully referenced neurology checklist.
Mode of action
- Lamotrigine modulates the voltage gated sodium channel (VGSC)
Indications
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Dosing
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Teratogenic risk
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References
- Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010; 9:413-424.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Trevathan E, Kerls SP, Hammer AE, Vuong A, Messenheimer JA. Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures. Pediatrics 2006; 118:e371-e378.
- Moore JL, Aggarwal P. Lamotrigine use in pregnancy. Expert Opin Pharmacother 2012; 13:1213-1216.
- Tennis P, Eldridge RR; International Lamotrigine Pregnancy Registry Scientific Advisory Committee. Preliminary results on pregnancy outcomes in women using lamotrigine. Epilepsia 2002; 43:1161-1167.
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