Lamotrigine: adverse effects
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lamotrigine: adverse effects. Spina bifida, Anencephaly, Transposition of the great arteries. Fully referenced neurology checklist.
Teratogenic malformation types
- Spina bifida
- Anencephaly
- Transposition of the great arteries
- Contradictory reports of the risk of cleft lip and palate
Dermatological side effects
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Neuropsychiatric side effects
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Movement disorders
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Systemic side effects
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References
- de Jong J, Garne E, de Jong-van den Berg LT, Wang H. The risk of specific congenital anomalies in relation to newer antiepileptic drugs: a literature review. Drugs Real World Outcomes 2016; 3:131-143.
- Jentink J, Dolk H, Loane MA, et al; EUROCAT Antiepileptic Study Working Group. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 2010; 341:c6581.
- Verrotti A, Mencaroni E, Castagnino M, Zaccara G. Foetal safety of old and new antiepileptic drugs. Expert Opin Drug Saf 2015; 14:1563-1571.
- Holmes LB, Baldwin EJ, Smith CR, et al. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008; 70:2152-2158.
- Dolk H, Jentink J, Loane M, Morris J, de Jong-van den Berg LT; EUROCAT Antiepileptic Drug Working Group. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008; 71:714-722.
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