KLHL11 paraneoplastic encephalitis: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
KLHL11 paraneoplastic encephalitis: clinical features. Brainstem encephalitis, Limbic encephalitis. Fully referenced neurology checklist.
Encephalitic features
- Brainstem encephalitis
- Limbic encephalitis
Cerebellar features
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Cerebral features
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Myoclonic features
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Other features
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Atypical features
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References
- Dubey D, Wilson MR, Clarkson B, et al. Expanded clinical phenotype, oncological associations, and immunopathologic insights of paraneoplastic kelch-like protein-11 encephalitis. JAMA Neurol 2020; 77:1420-1429.
- Mahmoud A, Dubey D, Goonetilleke A, Lee G, Elhabet S, Ahmad I, Dogar M, Jacob A. Paraneoplastic KLHL11 encephalitis presenting with progressive tinnitus, hearing loss and ataxia. Pract Neurol 2025; 25:443-447.
- Chai S, Liu G, Zhang Y. Anti-kelch-like protein 11 antibody-associated encephalitis: two case reports and literature review. BMC Neurol 2025; 25:297.
- Jin M, Brand T, Erdag Turgeon E, et al. Clinical manifestations, tumor associations, and long-term outcomes of anti-KLHL11 encephalitis. Neurol Neuroimmunol Neuroinflamm 2026; 13:e200597.
- Schwarz FK, Höftberger R, Endmayr V, et al. Vestibular and ocular motor phenotype in a case of paraneoplastic autoimmune kelch-like protein-11 encephalitis. Neurol Neuroimmunol Neuroinflamm 2026; 13:e200576.
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