Kleine-Levin syndrome (KLS): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Kleine-Levin syndrome (KLS): management. Methylphenidate, Amphetamines, Pemoline-piracetam-meclofenoxate. Fully referenced neurology checklist.
Acute treatment
- Methylphenidate
- Amphetamines
- Pemoline-piracetam-meclofenoxate
- Neuroleptics
- Intravenous steroids: these may shorten the duration of episodes
Prophylaxis
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Synonym
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References
- Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain 2005; 128:2763-2776.
- Dauvilliers Y, Mayer G, Lecendreux M, et al. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analysis. Neurology 2002; 59:1739-1745.
- Leu-Semenescu S, Le Corvec T, Groos E, Lavault S, Golmard JL, Arnulf I. Lithium therapy in Kleine-Levin syndrome: an open-label, controlled study in 130 patients. Neurology 2015; 85:1655-1662.
- Léotard A, Groos E, Chaumereuil C, et al. IV steroids during long episodes of Kleine-Levin syndrome. Neurology 2018; 90:e1488-e1492.
- Nebhinani N, Suthar N. Sleeping beauty syndrome: a case report and review of female cases reported from India. Indian J Psychol Med 2017; 39:357-360.
