Kleine-Levin syndrome (KLS): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Kleine-Levin syndrome (KLS): clinical features. This is a syndrome of episodic hypersomnia and compulsive eating. Fully referenced neurology checklist.
Demographic features
- This is a syndrome of episodic hypersomnia and compulsive eating
- It usually affects adolescent men: they account for 70% of cases
- The peak onset age is 14 years: the range is 11-21 years
Genetics
Locked: subscribe to see this section.
Precipitating causes
Locked: subscribe to see this section.
Core features
Locked: subscribe to see this section.
Features of hypersomnia
Locked: subscribe to see this section.
Eating disorders
Locked: subscribe to see this section.
Behavioural features
Locked: subscribe to see this section.
Compulsions
Locked: subscribe to see this section.
Neuropsychiatric features
Locked: subscribe to see this section.
Cognitive features
Locked: subscribe to see this section.
Other features
Locked: subscribe to see this section.
Differential diagnosis
Locked: subscribe to see this section.
Synonym
Locked: subscribe to see this section.
References
- Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain 2005; 128:2763-2776.
- Dauvilliers Y, Mayer G, Lecendreux M, et al. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analysis. Neurology 2002; 59:1739-1745.
- Al Shareef SM, Basit S, Li S, Pfister C, et al. Kleine-Levin syndrome is associated with LMOD3 variants. J Sleep Res 2018; e12718 (Epub ahead of print).
- Ambati A, Hillary R, Leu-Semenescu S, et al. Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. Proc Natl Acad Sci U S A 2021; 118:e2005753118.
- Groos E, Chaumereuil C, Flamand M, et al. Emerging psychiatric disorders in Kleine-Levin syndrome. J Sleep Res 2018:e12690.
- And 2 more. Subscribe to see the full list
