Idiopathic recurrent stupor (IRS)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Idiopathic recurrent stupor (IRS). Recurrent episodes of reduced responsiveness. The onset is with drowsiness. Fully referenced neurology checklist.
Clinical features
- Recurrent episodes of reduced responsiveness
- The onset is with drowsiness
- This is followed by staggering and behavioural abnormalities
- Deep sleep ensues: subjects may be aroused by vigorous stimuli
- There may be associated jerky movements
- Recovery is often spontaneous
- There is post-ictal amnesia
- Subjects are normal between episodes
Differential diagnosis
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Investigations
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Treatment
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Synonym
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Acronym
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References
- Gómez García A, Navas Vinagre I, Herranz Bárcenas A. Video NeuroImages: Idiopathic recurring stupor: an unusual clinical condition responding to flumazenil. Neurology 2021; 96:586.
- Lugaresi E, Montagna P, Tinuper P, et al. Endozepine stupor. Recurring stupor linked to endozepine-4 accumulation. Brain 1998; 121:127-133.
- Cortelli P, Avallone R, Baraldi M, et al. Endozepines in recurrent stupor. Sleep Med Rev 2005; 9:477-487.
- Asthana V, Agrawal S, Goel D, Sharma JP. Idiopathic recurrent stupor mimicking status epilepticus. Singapore Med J 2008; 49:e276-e277.
- Plazzi G, Rye D, Vignatelli L, Riva R, Lugaresi E. Idiopathic recurrent stupor: Munchausen by proxy and medical litigation. Sleep 2014; 37:211.
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