HyperCKaemia: neurological causes
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
HyperCKaemia: neurological causes. Motor neurone disease (MND), Spinal muscular atrophy (SMA). Fully referenced neurology checklist.
Anterior horn cell (AHC) causes
- Motor neurone disease (MND)
- Spinal muscular atrophy (SMA)
- Kennedy disease (X-linked spinal and bulbar muscular atrophy, SBMA)
Muscular dystrophy causes
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Other peripheral causes
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Central causes
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Macro CK: features
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References
- De Bleeker JL. How to approach the patient with muscular symptoms in the general neurological practice? Acta Neurol Belg 2005; 105:18-22.
- Lingaraju N, Rosenberg H. Unexplained increases in serum creatine kinase levels: its relation to malignant hyperthermia susceptibility. Anesth Analg 1991; 72:702-705.
- Kyriakides T, Angelini C, Schefer J, et al. EFNS guidelines on the diagnostic approach to pauci- or asymptomatic hyperCKemia. Eur J Neurol 2010; 17:767-773.
- Merlini L, Sabatelli P, Columbaro M, et al. Hyper-CK-emia as the sole manifestation of myotonic dystrophy type 2. Muscle Nerve 2005; 31:764-767.
- Nguyen K, Bassez G, Krahn M, et al. Phenotypic study in 40 patients with dysferlin gene mutations: high frequency of atypical phenotypes. Arch Neurol 2007; 64:1176-1182.
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