HyperCKaemia: assessment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
HyperCKaemia: assessment. HyperCKaemia: the CK is >1.5 times the upper limit of normal. Fully referenced neurology checklist.
Definitions
- HyperCKaemia: the CK is >1.5 times the upper limit of normal
- Mild elevation: the CK is <2 times the upper limit of normal
- Moderate elevation: the CK is 2-4 times the upper limit of normal
- Marked elevation: the CK is >4 times the upper limit of normal
Indicators of insignificant raised CK
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Adverse effects of hyperCKaemia: malignant hyperthermia (MH)
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Indications for muscle biopsy with hyperCKaemia
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Diagnostic outcomes of hyperCKaemia
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Predictors of establishing a diagnosis
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Diagnostic algorithm
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References
- Morandi L, Angelini C, Prelle A, et al. High plasma creatine kinase: review of the literature and proposal for a diagnostic algorithm. Neurol Sci 2006; 27:303-311.
- Kyriakides T, Angelini C, Schefer J, et al. EFNS guidelines on the diagnostic approach to pauci- or asymptomatic hyperCKemia. Eur J Neurol 2010; 17:767-773.
- De Bleeker JL. How to approach the patient with muscular symptoms in the general neurological practice? Acta Neurol Belg 2005; 105:18-22.
- Weglinski MR, Wedel DJ, Engel AG. Malignant hyperthermia testing in patients with persistently increased serum creatine kinase levels. Anesth Analg 1997; 84:1038-1041.
- Lingaraju N, Rosenberg H. Unexplained increases in serum creatine kinase levels: its relation to malignant hyperthermia susceptibility. Anesth Analg 1991; 72:702-705.
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