Ependymoma: genetics and demographics
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Ependymoma: genetics and demographics. The highest incidence is in children and young adults. Fully referenced neurology checklist.
Demographic features
- The highest incidence is in children and young adults
- Males are more frequently affected
- 90% of childhood ependymomas are intracranial
- Two-thirds of these are in the posterior fossa
High risk genetic mutations
Locked: subscribe to see this section.
Poor prognostic gene markers
Locked: subscribe to see this section.
References
- Rudà R, Reifenberger G, Frappaz D, et al. EANO guidelines for the diagnosis and treatment of ependymal tumors. Neuro Oncol 2018; 20:445-456.
- Pajtler KW, Witt H, Sill M, et al. Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 2015; 27:728-743.
- Andreiuolo F, Varlet P, Tauziède-Espariat A, et al. Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol 2018; doi: 10.1111/bpa.12659 (Epub ahead of print).
- Hosoya T, Kambe A, Nishimura Y, Sakamoto M, Maegaki Y, Kurosaki M. A pediatric case of Li-Fraumeni syndrome complicated with supratentorial anaplastic ependymoma. World Neurosurg 2018; pii: S1878-8750(18)31989-2.
