Edoxaban

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Edoxaban. Edoxaban is a factor Xa inhibitor. Fully referenced neurology checklist.

Pharmacology

  • Edoxaban is a factor Xa inhibitor

Dose

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Risk factors for bleeding

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Treatment of bleeding

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References

  1. Hart RG, Diener HC, Yang S, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke 2012; 43:1511-1517.
  2. Kreuzer J. Update on anti-coagulation in atrial fibrillation. Q J Med 2011; 104:747-760.
  3. Cervantes CE, Merino JL, Barrios V. Edoxaban for the prevention of stroke in patients with atrial fibrillation. Expert Rev Cardiovasc Ther 2019; 17:319-330. 
  4. Okumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med 2020 (Online ahead of print).
  5. Mikami T, Hirabayashi K, Okawa K, et al. Laboratory test predictors for major bleeding in elderly (≥80 years) patients with nonvalvular atrial fibrillation treated with edoxaban 15 mg: sub-analysis of the ELDERCARE-AF Trial. J Am Heart Assoc 2022; 11:e024970.
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