Drug-induced peripheral neuropathy (PN): causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Drug-induced peripheral neuropathy (PN): causes. Chloroquine, Dapsone, Isoniazid, Metronidazole, Nitrofurantoin. Fully referenced neurology checklist.

Antimicrobials

  • Chloroquine
  • Dapsone
  • Isoniazid
  • Metronidazole
  • Nitrofurantoin
  • Fluoroquinolones

Cardiac drugs

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Chemotherapy-induced PN (CIPN)

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Anti-programmed death 1 (PD-1) monoclonal antibodies

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Semaglutide (GLP-1 receptor antagonist)

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Other drugs

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Acronym

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References

  1. Burns TM, Mauermann ML. The evaluation of polyneuropathies. Neurology 2011; 76:S6-S13.
  2. Peters J, Staff NP. Update on toxic neuropathies. Curr Treat Options Neurol 2022; 24:203-216.
  3. Morales D, Pacurariu A, Slattery J, Pinheiro L, McGettigan P, Kurz X. Association between peripheral neuropathy and exposure to oral fluoroquinolone or amoxicillin-clavulanate therapy. JAMA Neurol; doi: 10.1001/jamaneurol.2019.0887 (Epub ahead of print).
  4. Burakgazi AZ, Polydefkis M, Höke A. Skin biopsy-proven flecainide-induced neuropathy. Muscle Nerve 2012; 45:144-146.
  5. Palace J, Shah R, Clough C. Flecainide induced peripheral neuropathy. BMJ 1992; 305:810.
  6. And 8 more. Subscribe to see the full list

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