Colchicine myoneuropathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Colchicine myoneuropathy. The onset is days to weeks after Colchicine treatment or change in renal function. Fully referenced neurology checklist.
Neuropathy features
- The onset is days to weeks after Colchicine treatment or change in renal function
- It presents with proximal weakness and pain
- There may be associated myotonia
- Gastrointestinal symptoms are not always present
Other manifestations of Colchicine toxicity
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Risk factors
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Differential diagnosis
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Raised enzyme levels
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Electromyogram (EMG): features
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Muscle biopsy
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Treatment
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References
- Rana SS, Giuliani MJ, Oddis CV, Lacomis D. Acute onset of colchicine myoneuropathy in cardiac transplant recipients: case studies of three patients. Clin Neurol Neurosurg 1997; 99:266-270.
- Kuncl RW, Duncan G, Watson D, Alderson K, Rogawski MA, Peper M. Colchicine myopathy and neuropathy. N Engl J Med 1987; 316:1562-1568.
- Wilbur K, Makowsky M. Colchicine myotoxicity: case reports and literature review. Pharmacotherapy 2004; 24:1784-192.
- Rutkove SB, De Girolami U, Preston DC, et al. Myotonia in colchicine myoneuropathy. Muscle Nerve 1996; 19:870-875.
- Duarte J, Cabezas C, Rodríguez F, Clavería LE, Palacin T. Colchicine-induced myopathy with myotonia. Muscle Nerve 1998; 21:550-551.
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