Down’s syndrome: neurological features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Down’s syndrome: neurological features. This develops in >90% of cases. It sets in at about the age of 40 years. Fully referenced neurology checklist.
Alzheimer’s disease
- This develops in >90% of cases
- It sets in at about the age of 40 years
- It is associated with gait dyspraxia
Other cognitive features
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Late onset myoclonic epilepsy in Down’s syndrome (LOMEDS)
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Other seizure features
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Vascular features
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Psychiatric features
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Gait impairment
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Other features
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References
- Santoro JD, Pagarkar D, Chu DT, et al. Neurologic complications of Down syndrome: a systematic review. J Neurol 2021; 268:4495-4509.
- Lott IT. Neurological phenotypes for Down syndrome across the life span. Prog Brain Res 2012; 197:101-121.
- Noble J. Natural history of Down's syndrome: a brief review for those involved in antenatal screening. J Med Screen 1998; 5:172-177.
- Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. Lancet Neurol 2010; 9:623-633.
- Ballard C, Mobley W, Hardy J, Williams G, Corbett A. Dementia in Down's syndrome. Lancet Neurol 2016; 15:622-636.
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