Doose syndrome: treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Doose syndrome: treatment. Ethosuximide: especially if absences predominate, Valproate. Fully referenced neurology checklist.

Anti-seizure medications (ASDs)

  • Ethosuximide: especially if absences predominate
  • Valproate
  • Lamotrigine: for generalised seizures
  • Levetiracetam: this is possibly effective
  • Zonisamide: this is possibly effective
  • Acetazolamide: this may be effective as adjunctive ASM

AEDs to avoid

Locked: subscribe to see this section.

Diet therapies

Locked: subscribe to see this section.

Synonym

Locked: subscribe to see this section.

References

  1. Kelley SA, Kossoff EH. Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress. Dev Med Child Neurol 2010; 52:988-993. 
  2. Kural Z, Ozer AF. Epileptic encephalopathies in adults and childhood. Epilepsy Res Treat 2012; 2012:205131.
  3. Oguni H, Fukuyama Y, Tanaka T, et al. Myoclonic-astatic epilepsy of early childhood-clinical and EEG analysis of myoclonic-astatic seizures, and discussions on the nosology of the syndrome. Brain Dev 2001; 23:757-764.
  4. Melikishvili G, Dulac O, Koniashvili O, et al. Adjunctive acetazolamide for drug-resistant seizures in SLC6A1-related neurodevelopmental disorder: An exploratory case series. Epilepsia Open 2025; 10:2009-2017.
  5. Palmer S, Towne MC, Pearl PL, et al. SLC6A1 mutation and ketogenic diet in epilepsy with myoclonic-atonic seizures. Pediatr Neurol 2016; 64:77-79.
  6. And 2 more. Subscribe to see the full list

Related checklists

Loading...